Harvey Pekar works at the VA Hospital in his hometown of Cleveland and fills his days with reading, writing, listening to jazz, and engaging in cerebral banter. When his buddy Robert Crumb earns wide acclaim for comic art, Harvey is inspired to write his own brand of comic books, and he makes the monotonous torture of his everyday foibles their focus. “American Splendor” is hugely successful, but Harvey still finds his life lacking. Enter the equally depressive Joyce Brabner, and united in codependence, the pair tackles life together.